Session 7 : Molecular biology – I

Both phage display and ribosome display systems can be used effectively to isolate large numbers of sequence-diverse antibodies from naı̈ve libraries. Once leads have been identified the same display technologies can be used to engineer the characteristics of the drug candidates to yield the desired in vivo efficacy. Ribosome display has a number of advantages over phage display resulting in significantly shorter timelines for therapeutic drug development. Using case studies we will demonstrate how ribosome display can effectively optimise antibodies to different types of targets. We will also highlight the ability of ribosome display to effectively explore the sequence space and its high throughput capacity.